The tankyrase‐specific inhibitor JW74 affects cell cycle progression and induces apoptosis and diffe...
The tankyrase‐specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
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United States: John Wiley & Sons Ltd
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Language
English
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United States: John Wiley & Sons Ltd
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Wnt/β‐catenin is a major regulator of stem cell self‐renewal and differentiation and this signaling pathway is aberrantly activated in a several cancers, including osteosarcoma (OS). Attenuation of Wnt/β‐catenin activity by tankyrase inhibitors is an appealing strategy in treatment of OS. The efficacy of the tankyrase inhibitor JW74 was evaluated i...
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Full title
The tankyrase‐specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3930388
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3930388
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ISSN
2045-7634
E-ISSN
2045-7634
DOI
10.1002/cam4.170
