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ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3940275

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

About this item

Full title

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2013, Vol.4 (1), p.2479-2479, Article 2479

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

ORM (yeast)-like protein isoform 3
(
ORMDL3
) has recently been identified as a candidate gene for susceptibility to asthma; however, the mechanisms by which it contributes to asthma pathogenesis are not well understood. Here we demonstrate a functional role for ORMDL3 in eosinophils in the context of allergic inflammation. Eosinophils rec...

Alternative Titles

Full title

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3940275

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3940275

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms3479

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