Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
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Author / Creator
Re, Diane B. , Le Verche, Virginia , Yu, Changhao , Amoroso, Mackenzie W. , Politi, Kristin A. , Phani, Sudarshan , Ikiz, Burcin , Hoffmann, Lucas , Koolen, Martijn , Nagata, Tetsuya , Papadimitriou, Dimitra , Nagy, Peter , Mitsumoto, Hiroshi , Kariya, Shingo , Wichterle, Hynek , Henderson, Christopher E. and Przedborski, Serge
Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Contents
Most cases of neurodegenerative diseases are sporadic, hindering the use of genetic mouse models to analyze disease mechanisms. Focusing on the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS), we therefore devised a fully humanized coculture model composed of human adult primary sporadic ALS (sALS) astrocytes and human embryonic stem-...
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Full title
Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3951532
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3951532
Other Identifiers
ISSN
0896-6273
E-ISSN
1097-4199
DOI
10.1016/j.neuron.2014.01.011
