RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute...
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia
About this item
Full title
Author / Creator
Papaemmanuil, Elli , Rapado, Inmaculada , Li, Yilong , Potter, Nicola E , Wedge, David C , Tubio, Jose , Alexandrov, Ludmil B , Van Loo, Peter , Cooke, Susanna L , Marshall, John , Martincorena, Inigo , Hinton, Jonathan , Gundem, Gunes , van Delft, Frederik W , Nik-Zainal, Serena , Jones, David R , Ramakrishna, Manasa , Titley, Ian , Stebbings, Lucy , Leroy, Catherine , Menzies, Andrew , Gamble, John , Robinson, Ben , Mudie, Laura , Raine, Keiran , O'Meara, Sarah , Teague, Jon W , Butler, Adam P , Cazzaniga, Giovanni , Biondi, Andrea , Zuna, Jan , Kempski, Helena , Muschen, Markus , Ford, Anthony M , Stratton, Michael R , Greaves, Mel and Campbell, Peter J
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Peter Campbell, Mel Greaves and colleagues use exome and whole-genome sequencing to characterize somatic mutations in childhood acute lymphoblastic leukemias with the
ETV6
-
RUNX1
fusion gene. They find that RAG-mediated deletions are the dominant mutational process.
The
ETV6
-
RUNX1
fusion gene, found in 25% of childhood...
Alternative Titles
Full title
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
Rapado, Inmaculada
Li, Yilong
Potter, Nicola E
Wedge, David C
Tubio, Jose
Alexandrov, Ludmil B
Van Loo, Peter
Cooke, Susanna L
Marshall, John
Martincorena, Inigo
Hinton, Jonathan
Gundem, Gunes
van Delft, Frederik W
Nik-Zainal, Serena
Jones, David R
Ramakrishna, Manasa
Titley, Ian
Stebbings, Lucy
Leroy, Catherine
Menzies, Andrew
Gamble, John
Robinson, Ben
Mudie, Laura
Raine, Keiran
O'Meara, Sarah
Teague, Jon W
Butler, Adam P
Cazzaniga, Giovanni
Biondi, Andrea
Zuna, Jan
Kempski, Helena
Muschen, Markus
Ford, Anthony M
Stratton, Michael R
Greaves, Mel
Campbell, Peter J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3960636
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3960636
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2874
