M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
In this study, the authors show that oligodendrocyte differentiation and remyelination after a CNS lesion coincides with a switch in microglial/macrophage polarization from a pro-inflammatory, M1, phenotype to an anti-inflammatory, M2, phenotype. This M2-dependant effect was in part mediated by secretion of the TGFβ family member, Activin-A.
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Full title
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3977045
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3977045
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3469
