Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Mouw
et al
. delineate a molecular pathway by which matrix stiffness promotes tumor malignancy. Upon matrix stiffening, integrin signaling is engaged, triggering a signaling cascade that regulates the protumorigenic microRNA miR-18a. This leads to downregulation of PTEN and activation of oncogenic signaling. The pathway provides a link betwee...
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Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3981899
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3981899
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3497
