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Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calci...

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calci...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3982139

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

About this item

Full title

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2014-04, Vol.5 (1), p.3628-3628, Article 3628

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Fragile X syndrome (FXS), the most common heritable form of mental retardation, is characterized by synaptic dysfunction. Synaptic transmission depends critically on presynaptic calcium entry via voltage-gated calcium (Ca
V
) channels. Here we show that the functional expression of neuronal N-type Ca
V
channels (Ca
V
2.2) is regul...

Alternative Titles

Full title

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3982139

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3982139

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms4628

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