Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro v...
Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway
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Author / Creator
Zhang, Yan-jun , Lu, Cheng-rong , Cao, Yan , Luo, Yuan , Bao, Rong-feng , Yan, Shu , Xue, Mei , Zhu, Feng , Wang, Zhe and Duan, Lian-ning
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aim： Histone H2AX is a novel tumor suppressor and its phosphorylation at the C terminus （Ser139 and Tyr142） is required for tumor cell apoptosis. The aim of the present study was to elucidate the mechanisms underlying imatinib-induced C-terminal phosphorylation of H2AX in chronic myelogenous leukemia cells in vitro. Methods： BCR-ABL-positive K562 c...
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Full title
Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4003371
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4003371
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/aps.2012.9
