LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2
LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Neurofibromatosis type 2 (NF2) is caused by mutations in the
NF2
gene that encodes a tumor-suppressor protein called merlin. NF2 is characterized by formation of multiple schwannomas, meningiomas and ependymomas. Merlin loss-of-function is associated with increased activity of Rac and p21-activated kinases (PAKs) and deregulation of cytoskele...
Alternative Titles
Full title
LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4016185
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4016185
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2013.320
