Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
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Author / Creator
Kim, Dae Gyu , Lee, Jin Young , Kwon, Nam Hoon , Fang, Pengfei , Zhang, Qian , Wang, Jing , Young, Nicolas L , Guo, Min , Cho, Hye Young , Mushtaq, Ameeq Ul , Jeon, Young Ho , Choi, Jin Woo , Han, Jung Min , Kang, Ho Woong , Joo, Jae Eun , Hur, Youn , Kang, Wonyoung , Yang, Heekyoung , Nam, Do-Hyun , Lee, Mi-Sook , Lee, Jung Weon , Kim, Eun-Sook , Moon, Aree , Kim, Kibom , Kim, Doyeun , Kang, Eun Joo , Moon, Youngji , Rhee, Kyung Hee , Han, Byung Woo , Yang, Jee Sun , Han, Gyoonhee , Yang, Won Suk , Lee, Cheolju , Wang, Ming-Wei and Kim, Sunghoon
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Beyond its canonical role in translation, lysyl-tRNA synthetase (KRS) stabilizes the prometastatic 67-kDa laminin receptor (67LR) in the plasma membrane. A small-molecule inhibitor of the KRS-67LR interaction modulates the KRS-promoted metastatic potential of 67LR without disrupting the normal function of each protein.
Lysyl-tRNA synthetase (KRS...
Alternative Titles
Full title
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
Authors, Artists and Contributors
Author / Creator
Lee, Jin Young
Kwon, Nam Hoon
Fang, Pengfei
Zhang, Qian
Wang, Jing
Young, Nicolas L
Guo, Min
Cho, Hye Young
Mushtaq, Ameeq Ul
Jeon, Young Ho
Choi, Jin Woo
Han, Jung Min
Kang, Ho Woong
Joo, Jae Eun
Hur, Youn
Kang, Wonyoung
Yang, Heekyoung
Nam, Do-Hyun
Lee, Mi-Sook
Lee, Jung Weon
Kim, Eun-Sook
Moon, Aree
Kim, Kibom
Kim, Doyeun
Kang, Eun Joo
Moon, Youngji
Rhee, Kyung Hee
Han, Byung Woo
Yang, Jee Sun
Han, Gyoonhee
Yang, Won Suk
Lee, Cheolju
Wang, Ming-Wei
Kim, Sunghoon
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4021855
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4021855
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1381
