Total Synthesis of a Functional Designer Eukaryotic Chromosome
Total Synthesis of a Functional Designer Eukaryotic Chromosome
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Full title
Author / Creator
Annaluru, Narayana , Muller, Héloïse , Mitchell, Leslie A. , Ramalingam, Sivaprakash , Stracquadanio, Giovanni , Richardson, Sarah M. , Dymond, Jessica S. , Kuang, Zheng , Scheifele, Lisa Z. , Cooper, Eric M. , Cai, Yizhi , Zeller, Karen , Agmon, Neta , Han, Jeffrey S. , Hadjithomas, Michalis , Tullman, Jennifer , Caravelli, Katrina , Cirelli, Kimberly , Guo, Zheyuan , London, Viktoriya , Yeluru, Apurva , Murugan, Sindurathy , Kandavelou, Karthikeyan , Agier, Nicolas , Fischer, Gilles , Yang, Kun , Martin, Andrew , Bilgel, Murat , Bohutski, Pavlo , Boulier, Kristin M. , Capaldo, Brian J. , Chang, Joy , Charoen, Kristie , Choi, Woo Jin , Deng, Peter , DiCarlo, James E. , Doong, Judy , Dunn, Jessilyn , Feinberg, Jason I. , Fernandez, Christopher , Floria, Charlotte E. , Gladowski, David , Hadidi, Pasha , Ishizuka, Isabel , Jabbari, Javaneh , Lau, Calvin Y. L. , Lee, Pablo A. , Li, Sean , Lin, Denise , Linder, Matthias E. , Ling, Jonathan , Liu, Jaime , Liu, Jonathan , London, Mariya , Ma, Henry , Mao, Jessica , McDade, Jessica E. , McMillan, Alexandra , Moore, Aaron M. , Oh, Won Chan , Ouyang, Yu , Patel, Ruchi , Paul, Marina , Paulsen, Laura C. , Qiu, Judy , Rhee, Alex , Rubashkin, Matthew G. , Soh, Ina Y. , Sotuyo, Nathaniel E. , Srinivas, Venkatesh , Suarez, Allison , Wong, Andy , Wong, Remus , Xie, Wei Rose , Xu, Yijie , Yu, Allen T. , Koszul, Romain , Bader, Joel S. , Boeke, Jef D. and Chandrasegaran, Srinivasan
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Rapid advances in DNA synthesis techniques have made it possible to engineer viruses, biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a functional 272,871–base pair designer eukaryotic chromosome, synlll, which is based on the 316,617–base pair native Saccharomyces cerevisiae chromosome III. Changes to synIII i...
Alternative Titles
Full title
Total Synthesis of a Functional Designer Eukaryotic Chromosome
Authors, Artists and Contributors
Author / Creator
Muller, Héloïse
Mitchell, Leslie A.
Ramalingam, Sivaprakash
Stracquadanio, Giovanni
Richardson, Sarah M.
Dymond, Jessica S.
Kuang, Zheng
Scheifele, Lisa Z.
Cooper, Eric M.
Cai, Yizhi
Zeller, Karen
Agmon, Neta
Han, Jeffrey S.
Hadjithomas, Michalis
Tullman, Jennifer
Caravelli, Katrina
Cirelli, Kimberly
Guo, Zheyuan
London, Viktoriya
Yeluru, Apurva
Murugan, Sindurathy
Kandavelou, Karthikeyan
Agier, Nicolas
Fischer, Gilles
Yang, Kun
Martin, Andrew
Bilgel, Murat
Bohutski, Pavlo
Boulier, Kristin M.
Capaldo, Brian J.
Chang, Joy
Charoen, Kristie
Choi, Woo Jin
Deng, Peter
DiCarlo, James E.
Doong, Judy
Dunn, Jessilyn
Feinberg, Jason I.
Fernandez, Christopher
Floria, Charlotte E.
Gladowski, David
Hadidi, Pasha
Ishizuka, Isabel
Jabbari, Javaneh
Lau, Calvin Y. L.
Lee, Pablo A.
Li, Sean
Lin, Denise
Linder, Matthias E.
Ling, Jonathan
Liu, Jaime
Liu, Jonathan
London, Mariya
Ma, Henry
Mao, Jessica
McDade, Jessica E.
McMillan, Alexandra
Moore, Aaron M.
Oh, Won Chan
Ouyang, Yu
Patel, Ruchi
Paul, Marina
Paulsen, Laura C.
Qiu, Judy
Rhee, Alex
Rubashkin, Matthew G.
Soh, Ina Y.
Sotuyo, Nathaniel E.
Srinivas, Venkatesh
Suarez, Allison
Wong, Andy
Wong, Remus
Xie, Wei Rose
Xu, Yijie
Yu, Allen T.
Koszul, Romain
Bader, Joel S.
Boeke, Jef D.
Chandrasegaran, Srinivasan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4033833
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4033833
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1249252
