Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study
Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study
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Author / Creator
Owen, David R , Guo, Qi , Kalk, Nicola J , Colasanti, Alessandro , Kalogiannopoulou, Dimitra , Dimber, Rahul , Lewis, Yvonne L , Libri, Vincenzo , Barletta, Julien , Ramada-Magalhaes, Joaquim , Kamalakaran, Aruloly , Nutt, David J , Passchier, Jan , Matthews, Paul M , Gunn, Roger N and Rabiner, Eugenii A
Publisher
London, England: SAGE Publications
Journal title
Language
English
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Publisher
London, England: SAGE Publications
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Contents
Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quantify neuroinflammation. Translocator protein is expressed throughout the brain, and therefore a classical reference region approach cannot be used to estimate binding potential (BPND). Here, we used blockade of the TSPO radioligand [11C]PBR28 with the...
Alternative Titles
Full title
Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4050243
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4050243
Other Identifiers
ISSN
0271-678X
E-ISSN
1559-7016
DOI
10.1038/jcbfm.2014.46
