Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
About this item
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
To systematically investigate the impact of immune stimulation upon regulatory variant activity, we exposed primary monocytes from 432 healthy Europeans to interferon-γ (IFN-γ) or differing durations of lipopolysaccharide and mapped expression quantitative trait loci (eQTLs). More than half of cis-eQTLs identified, involving hundreds of genes and a...
Alternative Titles
Full title
Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4064786
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4064786
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1246949
