Targeting the β secretase BACE1 for Alzheimer's disease therapy
Targeting the β secretase BACE1 for Alzheimer's disease therapy
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Publisher
England: Elsevier Ltd
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Language
English
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England: Elsevier Ltd
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Summary The β secretase, widely known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), initiates the production of the toxic amyloid β (Aβ) that plays a crucial early part in Alzheimer's disease pathogenesis. BACE1 is a prime therapeutic target for lowering cerebral Aβ concentrations in Alzheimer's disease, and clinical development of...
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Full title
Targeting the β secretase BACE1 for Alzheimer's disease therapy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4086426
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4086426
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ISSN
1474-4422
E-ISSN
1474-4465
DOI
10.1016/S1474-4422(13)70276-X
