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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4089965

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

About this item

Full title

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Publisher

United States: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2014-01, Vol.343 (6166), p.84-87

Language

English

Formats

Publication information

Publisher

United States: American Association for the Advancement of Science

More information

Scope and Contents

Contents

The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)–associated nuclease Cas9 to modify specific genomic loci suggests a new way to interrogate gene function on a genome-wide scale. We show that lentiviral delivery of a genome-scale CRISPR-Cas9 knockout (GeCKO) library targeting 18,080 genes with 64,7...

Alternative Titles

Full title

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4089965

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4089965

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.1247005

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