PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
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Author / Creator
Yang, Liangchun , Xie, Min , Yang, Minghua , Yu, Yan , Zhu, Shan , Hou, Wen , Kang, Rui , Lotze, Michael T. , Billiar, Timothy R. , Wang, Haichao , Cao, Lizhi and Tang, Daolin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Increasing evidence suggests the important role of metabolic reprogramming in the regulation of the innate inflammatory response, but the underlying mechanism remains unclear. Here we provide evidence to support a novel role for the pyruvate kinase M2 (PKM2)-mediated Warburg effect, namely aerobic glycolysis, in the regulation of high-mobility grou...
Alternative Titles
Full title
PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4104986
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4104986
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5436
