Copper is required for oncogenic BRAF signalling and tumorigenesis
Copper is required for oncogenic BRAF signalling and tumorigenesis
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Tumorigenesis driven by the oncogene
BRAF
V600E
is shown both to depend on the BRAF substrates MEK1/2 associating with copper, and to be sensitive to copper-chelating drugs, suggesting merit in testing such drugs for the treatment of
BRAF
mutation-positive cancers.
A role for copper in BRAF cancers
A large proportion of melanom...
Alternative Titles
Full title
Copper is required for oncogenic BRAF signalling and tumorigenesis
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4138975
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4138975
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13180
