cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cytosolic DNA induces type I interferon via activation of STING; the immediate STING activator is produced by the recently identified DNA sensor cGAS and is shown here to be an unorthodox cyclic dinucleotide harbouring a 2′-5′ linkage between guanosine and adenosine.
DNA sensing by cGAS
The mechanism of sensing and signalling of cytosolic DNA...
Alternative Titles
Full title
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4143541
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4143541
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12306
