PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding
PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Activation of central PPARγ promotes food intake and body weight gain; however, the identity of the neurons that express PPARγ and mediate the effect of this nuclear receptor on energy homeostasis is unknown. Here, we determined that selective ablation of PPARγ in murine proopiomelanocortin (POMC) neurons decreases peroxisome density, elevates reac...
Alternative Titles
Full title
PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4151211
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4151211
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI76220
