Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
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Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Contents
Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations (“strains”) in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefinitely propagates distinct amylo...
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Full title
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4171396
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4171396
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ISSN
0896-6273
E-ISSN
1097-4199
DOI
10.1016/j.neuron.2014.04.047
