IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The MAPK cascade scaffolding protein IQGAP1, although dispensable for normal epithelial homeostasis, is required for RAS- and RAF-driven tumorigenesis in mouse tumor models. Accordingly, peptide-specific disruption of the interaction between IQGAP1 and ERK1/2 can bypass acquired resistance of vemurafenib-treated BRAF-mutant melanomas and extend the...
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Full title
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4190012
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4190012
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3165
