The clinical implication and molecular mechanism of preferential IL-4 production by modified glycoli...
The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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United States: American Society for Clinical Investigation
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Contents
OCH, a sphingosine-truncated analog of alpha-galactosylceramide (alphaGC), is a potential therapeutic reagent for a variety of Th1-mediated autoimmune diseases through its selective induction of Th2 cytokines from natural killer T (NKT) cells. We demonstrate here that the NKT cell production of IFN-gamma is more susceptible to the sphingosine lengt...
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Full title
The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_419488
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_419488
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/jci200420862
