Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from hig...
Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas
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Author / Creator
Bechet, Denise , Gielen, Gerrit G. H. , Korshunov, Andrey , Pfister, Stefan M. , Rousso, Caterina , Faury, Damien , Fiset, Pierre-Olivier , Benlimane, Naciba , Lewis, Peter W. , Lu, Chao , David Allis, C. , Kieran, Mark W. , Ligon, Keith L. , Pietsch, Torsten , Ellezam, Benjamin , Albrecht, Steffen and Jabado, Nada
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in both H3.3 and H3.1 variants, is associated with rapid fatal outcome, and occurs specifically in...
Alternative Titles
Full title
Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4201745
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4201745
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-014-1337-4
