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Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteocl...

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteocl...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205484

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclast-specific inactivation of the...

Alternative Titles

Full title

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205484

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205484

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms6215

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