NAD+ protects against EAE by regulating CD4+ T-cell differentiation
NAD+ protects against EAE by regulating CD4+ T-cell differentiation
About this item
Full title
Author / Creator
Tullius, Stefan G. , Biefer, Hector Rodriguez Cetina , Li, Suyan , Trachtenberg, Alexander J. , Edtinger, Karoline , Quante, Markus , Krenzien, Felix , Uehara, Hirofumi , Yang, Xiaoyong , Kissick, Haydn T. , Kuo, Winston P. , Ghiran, Ionita , de la Fuente, Miguel A. , Arredouani, Mohamed S. , Camacho, Virginia , Tigges, John C. , Toxavidis, Vasilis , El Fatimy, Rachid , Smith, Brian D. , Vasudevan, Anju and ElKhal, Abdallah
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
CD4
+
T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD
+
) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4
+
IFNγ
+
IL-10
+
T cells and reverses dis...
Alternative Titles
Full title
NAD+ protects against EAE by regulating CD4+ T-cell differentiation
Authors, Artists and Contributors
Author / Creator
Biefer, Hector Rodriguez Cetina
Li, Suyan
Trachtenberg, Alexander J.
Edtinger, Karoline
Quante, Markus
Krenzien, Felix
Uehara, Hirofumi
Yang, Xiaoyong
Kissick, Haydn T.
Kuo, Winston P.
Ghiran, Ionita
de la Fuente, Miguel A.
Arredouani, Mohamed S.
Camacho, Virginia
Tigges, John C.
Toxavidis, Vasilis
El Fatimy, Rachid
Smith, Brian D.
Vasudevan, Anju
ElKhal, Abdallah
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205890
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205890
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6101
