Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's di...
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Tau cleavage and aggregation, key processes in many neurodegenerative diseases, can be reduced by blocking the activity of a protease called asparagine endopeptidase.
Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases, including Alzheimer's...
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Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4224595
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4224595
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3700
