Histone H3.3 and its proteolytically processed form drive a cellular senescence programme
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The process of cellular senescence generates a repressive chromatin environment, however, the role of histone variants and histone proteolytic cleavage in senescence remains unclear. Here, using models of oncogene-induced and replicative senescence, we report novel histone H3 tail cleavage events mediated by the protease Cathepsin L. We find that c...
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Full title
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4235654
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4235654
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6210
