Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons
Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP–C patient fibroblasts and NP–C mouse Purkinje neurons (PNs) due to defective vascular endothelial growth facto...
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Full title
Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4263144
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4263144
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6514
