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ArticlesPeer ReviewedFull Text
Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers
Author / Creator:Muro, Silvia ; Garnacho, Carmen ; Champion, Julie A ; Leferovich, John ; Gajewski, Christine ; Schuchman, Edward H ; Mitragotri, Samir ; Muzykantov, Vladimir R
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy, 2008-08, Vol.16 (8), p.1450-1458
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ArticlesPeer ReviewedFull Text
The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells
Author / Creator:Kunkel, Thaddeus J. ; Townsend, Alice ; Sullivan, Kyle A. ; Merlet, Jean ; Schuchman, Edward H. ; Jacobson, Daniel A. ; Lieberman, Andrew P.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-07, Vol.14 (1), p.3964-3964, Article 3964
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ArticlesPeer ReviewedFull Text
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
Author / Creator:Ju Youn Lee ; Han, Seung Hoon ; Park, Min Hee ; Baek, Bosung ; Im-Sook Song ; Min-Koo, Choi ; Takuwa, Yoh ; Ryu, Hoon ; Kim, Seung Hyun ; He, Xingxuan ; Schuchman, Edward H ; Jae-Sung Bae ; Jin, Hee Kyung
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-04, Vol.9, p.1-14
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ArticlesPeer ReviewedFull Text
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
Author / Creator:Lee, Ju Youn ; Han, Seung Hoon ; Park, Min Hee ; Song, Im-Sook ; Choi, Min-Koo ; Yu, Eunsoo ; Park, Cheol-Min ; Kim, Hee-Jin ; Kim, Seung Hyun ; Schuchman, Edward H. ; Jin, Hee Kyung ; Bae, Jae-sung
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-05, Vol.11 (1), p.2358-19, Article 2358
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ArticlesPeer ReviewedFull Text
Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase
Author / Creator:He, Xingxuan ; Schuchman, Edward H.
Publisher:Switzerland: MDPI AG
Journal title:Biomolecules (Basel, Switzerland), 2023-11, Vol.13 (11), p.1623
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ArticlesPeer ReviewedFull Text
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease
Author / Creator:Choi, Byung Jo ; Park, Min Hee ; Park, Kang Ho ; Han, Wan Hui ; Yoon, Hee Ji ; Jung, Hye Yoon ; Hong, Ju Yeon ; Chowdhury, Md Riad ; Kim, Kyung Yeol ; Lee, Jihoon ; Song, Im-Sook ; Pang, Minyeong ; Choi, Min-Koo ; Gulbins, Erich ; Reichel, Martin ; Kornhuber, Johannes ; Hong, Chang-Won ; Kim, Changho ; Kim, Seung Hyun ; Schuchman, Edward H. ; Jin, Hee Kyung ; Bae, Jae-sung
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-03, Vol.14 (1), p.1631-1631, Article 1631
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ArticlesPeer ReviewedFull Text
Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency
Author / Creator:Gaudioso, Ángel ; Jiang, Xuntian ; Casas, Josefina ; Schuchman, Edward H ; Ledesma, María Dolores
Publisher:London: Springer Nature B.V
Journal title:Cell death & disease, 2023-04, Vol.14 (4), p.248
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ArticlesPeer ReviewedFull Text
New paradigms for the treatment of lysosomal storage diseases: targeting the endocannabinoid system as a therapeutic strategy
Author / Creator:Schuchman, Edward H. ; Ledesma, Maria D. ; Simonaro, Calogera M.
Publisher:England: BioMed Central Ltd
Journal title:Orphanet journal of rare diseases, 2021-03, Vol.16 (1), p.151-151, Article 151
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ArticlesPeer ReviewedFull Text
Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs
Author / Creator:Simonaro, Calogera M. ; Tomatsu, Shunji ; Sikora, Tracy ; Kubaski, Francyne ; Frohbergh, Michael ; Guevara, Johana M. ; Wang, Raymond Y. ; Vera, Moin ; Kang, Jennifer L. ; Smith, Lachlan J. ; Schuchman, Edward H. ; Haskins, Mark E.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-04, Vol.11 (4), p.e0153136
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ArticlesPeer ReviewedFull Text
Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer
Author / Creator:Savić, Radoslav ; He, Xingxuan ; Fiel, Isabel ; Schuchman, Edward H.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-05, Vol.8 (5), p.e65620
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Newsletter articlesFull Text
Sinai School Medicine and Schuchman Edward H File WIPO Patent Application for Diagnosis and Detection of Disease Conditions Modulated by Activation of the Sphingolipid Pathway
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Medical Patent News, 2013
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ArticlesPeer ReviewedFull Text
Involvement of the Toll-like receptor 4 pathway and use of TNF-α antagonists for treatment of the mucopolysaccharidoses
Author / Creator:Simonaro, Calogera M ; Ge, Yi ; Eliyahu, Efrat ; He, Xingxuan ; Jepsen, Karl J ; Schuchman, Edward H
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (1), p.222-227
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ArticlesPeer ReviewedFull Text
Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses
Author / Creator:Schuchman, Edward H. ; Ge, Yi ; Lai, Alon ; Borisov, Yury ; Faillace, Meghan ; Eliyahu, Efrat ; He, Xingxuan ; Iatridis, James ; Vlassara, Helen ; Striker, Gary ; Simonaro, Calogera M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-01, Vol.8 (1), p.e54459
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Newsletter articlesFull Text
Schuchman Edward H, Simonaro Calogera M, Striker Gary E, Vlassara Helen and Icahn School of Medicine at Mount Sinai Submit Patent Application for Anti-TNF-Alpha Therapy for the Mucopolysaccharidoses a...
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Pharmaceutical Patent News, 2014
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ArticlesPeer ReviewedFull Text
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
Author / Creator:Pewzner‐Jung, Yael ; Tavakoli Tabazavareh, Shaghayegh ; Grassmé, Heike ; Becker, Katrin Anne ; Japtok, Lukasz ; Steinmann, Jörg ; Joseph, Tammar ; Lang, Stephan ; Tuemmler, Burkhard ; Schuchman, Edward H ; Lentsch, Alex B ; Kleuser, Burkhard ; Edwards, Michael J ; Futerman, Anthony H ; Gulbins, Erich
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2014-09, Vol.6 (9), p.1205-1214
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ArticlesPeer ReviewedFull Text
Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling
Author / Creator:Bartoll, Adrián ; Toledano‐Zaragoza, Ana ; Casas, Josefina ; Guzmán, Manuel ; Schuchman, Edward H ; Ledesma, María Dolores
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2020-11, Vol.12 (11), p.e11776-n/a
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ArticlesPeer ReviewedFull Text
Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons
Author / Creator:Lee, Hyun ; Lee, Jong Kil ; Park, Min Hee ; Hong, Yu Ri ; Marti, Hugo H. ; Kim, Hyongbum ; Okada, Yohei ; Otsu, Makoto ; Seo, Eul-Ju ; Park, Jae-Hyung ; Bae, Jae-Hoon ; Okino, Nozomu ; He, Xingxuan ; Schuchman, Edward H. ; Bae, Jae-sung ; Jin, Hee Kyung
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-11, Vol.5 (1), p.5514-5514, Article 5514
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ArticlesPeer ReviewedFull Text
Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment
Author / Creator:Frohbergh, Michael ; Ge, Yi ; Meng, Fanli ; Karabul, Nesrin ; Solyom, Alexander ; Lai, Alon ; Iatridis, James ; Schuchman, Edward H. ; Simonaro, Calogera M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-06, Vol.9 (6), p.e100882
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ArticlesPeer ReviewedFull Text
Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI
Author / Creator:Eliyahu, Efrat ; Wolfson, Theodore ; Ge, Yi ; Jepsen, Karl J. ; Schuchman, Edward H. ; Simonaro, Calogera M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011-08, Vol.6 (8), p.e22447-e22447
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ArticlesPeer ReviewedFull Text
Systemic ceramide accumulation leads to severe and varied pathological consequences
Author / Creator:Alayoubi, Abdulfatah M. ; Wang, James C. M. ; Au, Bryan C. Y. ; Carpentier, Stéphane ; Garcia, Virginie ; Dworski, Shaalee ; El‐Ghamrasni, Samah ; Kirouac, Kevin N. ; Exertier, Mathilde J. ; Xiong, Zi Jian ; Privé, Gilbert G. ; Simonaro, Calogera M. ; Casas, Josefina ; Fabrias, Gemma ; Schuchman, Edward H. ; Turner, Patricia V. ; Hakem, Razqallah ; Levade, Thierry ; Medin, Jeffrey A.
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2013-06, Vol.5 (6), p.827-842
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Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers

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The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

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Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

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N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

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Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase

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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

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Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency

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New paradigms for the treatment of lysosomal storage diseases: targeting the endocannabinoid system as a therapeutic strategy

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Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs

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Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer

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Sinai School Medicine and Schuchman Edward H File WIPO Patent Application for Diagnosis and Detection of Disease Conditions Modulated by Activation of the Sphingolipid Pathway

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Involvement of the Toll-like receptor 4 pathway and use of TNF-α antagonists for treatment of the mucopolysaccharidoses

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Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses

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Schuchman Edward H, Simonaro Calogera M, Striker Gary E, Vlassara Helen and Icahn School of Medicine at Mount Sinai Submit Patent Application for Anti-TNF-Alpha Therapy for the Mucopolysaccharidoses a...

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Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa

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Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

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Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

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Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

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Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI

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Systemic ceramide accumulation leads to severe and varied pathological consequences

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