MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cance...
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers
About this item
Full title
Author / Creator
Mohseni, Morassa , Cidado, Justin , Croessmann, Sarah , Cravero, Karen , Cimino-Mathews, Ashley , Wong, Hong Yuen , Scharpf, Rob , Zabransky, Daniel J , Abukhdeir, Abde M , Garay, Joseph P , Wang, Grace M , Beaver, Julia A , Cochran, Rory L , Blair, Brian G , Rosen, D Marc , Erlanger, Bracha , Argani, Pedram , Hurley, Paula J , Lauring, Josh and Park, Ben Ho
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We found MACROD2 is amplified and overexpressed in metast...
Alternative Titles
Full title
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers
Authors, Artists and Contributors
Author / Creator
Cidado, Justin
Croessmann, Sarah
Cravero, Karen
Cimino-Mathews, Ashley
Wong, Hong Yuen
Scharpf, Rob
Zabransky, Daniel J
Abukhdeir, Abde M
Garay, Joseph P
Wang, Grace M
Beaver, Julia A
Cochran, Rory L
Blair, Brian G
Rosen, D Marc
Erlanger, Bracha
Argani, Pedram
Hurley, Paula J
Lauring, Josh
Park, Ben Ho
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4267353
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4267353
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1408650111
