Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
About this item
Full title
Author / Creator
Fowler, Benjamin J. , Gelfand, Bradley D. , Kim, Younghee , Kerur, Nagaraj , Tarallo, Valeria , Hirano, Yoshio , Amarnath, Shoba , Fowler, Daniel H. , Radwan, Marta , Young, Mark T. , Pittman, Keir , Kubes, Paul , Agarwal, Hitesh K. , Parang, Keykavous , Hinton, David R. , Bastos-Carvalho, Ana , Li, Shengjian , Yasuma, Tetsuhiro , Mizutani, Takeshi , Yasuma, Reo , Wright, Charles and Ambati, Jayakrishna
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that also requires reverse transcriptase for its life cycle)–derived RNAs activate P2X7 and the NLRP3 inflammasome to cause cell death of the retinal pigment epithelium in geographic atrophy, a typ...
Alternative Titles
Full title
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
Authors, Artists and Contributors
Author / Creator
Gelfand, Bradley D.
Kim, Younghee
Kerur, Nagaraj
Tarallo, Valeria
Hirano, Yoshio
Amarnath, Shoba
Fowler, Daniel H.
Radwan, Marta
Young, Mark T.
Pittman, Keir
Kubes, Paul
Agarwal, Hitesh K.
Parang, Keykavous
Hinton, David R.
Bastos-Carvalho, Ana
Li, Shengjian
Yasuma, Tetsuhiro
Mizutani, Takeshi
Yasuma, Reo
Wright, Charles
Ambati, Jayakrishna
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4274127
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4274127
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1261754
