The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
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Author / Creator
Chen, Jiwang , Tang, Haiyang , Sysol, Justin R , Moreno-Vinasco, Liliana , Shioura, Krystyna M , Chen, Tianji , Gorshkova, Irina , Wang, Lichun , Huang, Long Shuang , Usatyuk, Peter V , Sammani, Saad , Zhou, Guofei , Raj, J Usha , Garcia, Joe G N , Berdyshev, Evgeny , Yuan, Jason X-J , Natarajan, Viswanathan and Machado, Roberto F
Publisher
United States: American Thoracic Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Thoracic Society
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Scope and Contents
Contents
Sphingosine kinases (SphKs) 1 and 2 regulate the synthesis of the bioactive sphingolipid sphingosine-1-phosphate (S1P), an important lipid mediator that promotes cell proliferation, migration, and angiogenesis.
We aimed to examine whether SphKs and their product, S1P, play a role in the development of pulmonary arterial hypertension (PAH).
Sp...
Alternative Titles
Full title
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4299585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4299585
Other Identifiers
ISSN
1073-449X
E-ISSN
1535-4970
DOI
10.1164/rccm.201401-0121OC
