Notch inhibition allows oncogene-independent generation of iPS cells
Notch inhibition allows oncogene-independent generation of iPS cells
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The addition of a Notch signaling inhibitor to both mouse and human keratinocytes bypasses the use of oncogenes and p53 to increase transcription factor mediated–pluripotent stem cell reprogramming through blocking p21 expression.
The reprogramming of somatic cells to pluripotency using defined transcription factors holds great promise for biome...
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Full title
Notch inhibition allows oncogene-independent generation of iPS cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4310751
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4310751
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1552
