The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Kwangseog Ahn and colleagues show that the RNase activity of SAMHD1 accounts for its ability to limit HIV-1 replication by degrading HIV-1 RNA.
The HIV-1 restriction factor SAM domain– and HD domain–containing protein 1 (SAMHD1)
1
,
2
is proposed to inhibit HIV-1 replication by depleting the intracellular dNTP pool
3
,
4
...
Alternative Titles
Full title
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4318684
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4318684
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3626
