Longevity effect of IGF‐1R+/− mutation depends on genetic background‐specific receptor activation
Longevity effect of IGF‐1R+/− mutation depends on genetic background‐specific receptor activation
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Publisher
England: John Wiley & Sons, Inc
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Language
English
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Publisher
England: John Wiley & Sons, Inc
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Summary
Growth hormone (GH) and insulin‐like growth factor (IGF) signaling regulates lifespan in mice. The modulating effects of genetic background gained much attention because it was shown that life‐prolonging effects in Snell dwarf and GH receptor knockout vary between mouse strains. We previously reported that heterozygous IGF‐1R inactivatio...
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Full title
Longevity effect of IGF‐1R+/− mutation depends on genetic background‐specific receptor activation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4326867
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4326867
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ISSN
1474-9718
E-ISSN
1474-9726,1474-9728
DOI
10.1111/acel.12145
