Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
If deprived of exogenous glutamine, naive mouse embryonic stem cells are shown to be capable of generating the amino acid from other sources to enable their proliferation; the stem cells use glutamine and glucose catabolism to maintain a high level of intracellular α-ketoglutarate and promote demethylation of chromatin and ensure sufficient express...
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Full title
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4336218
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4336218
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13981
