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Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conju...

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conju...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4345600

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

About this item

Full title

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (8), p.2401-2406

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Significance Self-administered insulin is the most important therapeutic to provide control over blood glucose levels for patients with type-1 diabetes. However, standard insulin therapy introduces a number of complications and subsequent issues with control of blood glucose levels. Here, we prepared a derivative of insulin with a molecular switch...

Alternative Titles

Full title

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4345600

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4345600

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1424684112

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