The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Activating RAS mutations are common in human tumors. These mutations are often markers for resistance to therapy and subsequent poor prognosis. So far, targeting the RAF-MEK-ERK and PI3K-AKT signaling pathways downstream of RAS is the only promising approach in the treatment of cancer patients harboring RAS mutations. RAL GTPase, another downstream...
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Full title
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4349922
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4349922
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ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/aps.2014.129
