Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington’s dise...
Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington’s disease
About this item
Full title
Author / Creator
Valenza, M , Marullo, M , Di Paolo, E , Cesana, E , Zuccato, C , Biella, G and Cattaneo, E
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
In the adult brain, neurons require local cholesterol production, which is supplied by astrocytes through apoE-containing lipoproteins. In Huntington’s disease (HD), such cholesterol biosynthesis in the brain is severely reduced. Here we show that this defect, occurring in astrocytes, is detrimental for HD neurons. Astrocytes bearing the huntingtin...
Alternative Titles
Full title
Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington’s disease
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4356339
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4356339
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2014.162
