Loss of hepatic chaperone‐mediated autophagy accelerates proteostasis failure in aging
Loss of hepatic chaperone‐mediated autophagy accelerates proteostasis failure in aging
About this item
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Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
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Publisher
England: John Wiley & Sons, Inc
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Contents
Summary
Chaperone‐mediated autophagy (CMA), a cellular process that contributes to protein quality control through targeting of a subset of cytosolic proteins to lysosomes for degradation, undergoes a functional decline with age. We have used a mouse model with liver‐specific defective CMA to identify changes in proteostasis attributable to redu...
Alternative Titles
Full title
Loss of hepatic chaperone‐mediated autophagy accelerates proteostasis failure in aging
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4364837
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4364837
Other Identifiers
ISSN
1474-9718
E-ISSN
1474-9726
DOI
10.1111/acel.12310
