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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4372335

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

About this item

Full title

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

Publisher

Washington: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2014-09, Vol.345 (6203), p.1509-1512

Language

English

Formats

Publication information

Publisher

Washington: American Association for the Advancement of Science

More information

Scope and Contents

Contents

The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromis...

Alternative Titles

Full title

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4372335

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4372335

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.1256337

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