Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pa...
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
About this item
Full title
Author / Creator
Gomez, Ivan G , MacKenna, Deidre A , Johnson, Bryce G , Kaimal, Vivek , Roach, Allie M , Ren, Shuyu , Nakagawa, Naoki , Xin, Cuiyan , Newitt, Rick , Pandya, Shweta , Xia, Tai-He , Liu, Xueqing , Borza, Dorin-Bogdan , Grafals, Monica , Shankland, Stuart J , Himmelfarb, Jonathan , Portilla, Didier , Liu, Shiguang , Chau, B Nelson and Duffield, Jeremy S
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling. Here, we developed highly specific oligonucleotides that distribute to the kidney and inhibit mi...
Alternative Titles
Full title
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
Authors, Artists and Contributors
Author / Creator
MacKenna, Deidre A
Johnson, Bryce G
Kaimal, Vivek
Roach, Allie M
Ren, Shuyu
Nakagawa, Naoki
Xin, Cuiyan
Newitt, Rick
Pandya, Shweta
Xia, Tai-He
Liu, Xueqing
Borza, Dorin-Bogdan
Grafals, Monica
Shankland, Stuart J
Himmelfarb, Jonathan
Portilla, Didier
Liu, Shiguang
Chau, B Nelson
Duffield, Jeremy S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4382246
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4382246
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI75852
