Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9...
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
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Full title
Author / Creator
Fitzgerald, Kevin, Dr , Frank-Kamenetsky, Maria, PhD , Shulga-Morskaya, Svetlana, MSc , Liebow, Abigail, BS , Bettencourt, Brian R, PhD , Sutherland, Jessica E, PhD , Hutabarat, Renta M, PhD , Clausen, Valerie A, PhD , Karsten, Verena, PhD , Cehelsky, Jeffrey, MBA , Nochur, Saraswathy V, PhD , Kotelianski, Victor, MD , Horton, Jay, MD , Mant, Timothy, MD , Chiesa, Joseph, MD , Ritter, James, MD , Munisamy, Malathy, MD , Vaishnaw, Akshay K, MD , Gollob, Jared A, MD and Simon, Amy, MD
Publisher
Kidlington: Elsevier Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Kidlington: Elsevier Ltd
Subjects
More information
Scope and Contents
Contents
Summary Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that loss-of-function mutations in PCSK9 result in reduced plasma LDL cholesterol and decreased risk of coronary heart disease. We aimed to investigate the safety and efficacy of ALN-PCS, a small...
Alternative Titles
Full title
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
Authors, Artists and Contributors
Author / Creator
Frank-Kamenetsky, Maria, PhD
Shulga-Morskaya, Svetlana, MSc
Liebow, Abigail, BS
Bettencourt, Brian R, PhD
Sutherland, Jessica E, PhD
Hutabarat, Renta M, PhD
Clausen, Valerie A, PhD
Karsten, Verena, PhD
Cehelsky, Jeffrey, MBA
Nochur, Saraswathy V, PhD
Kotelianski, Victor, MD
Horton, Jay, MD
Mant, Timothy, MD
Chiesa, Joseph, MD
Ritter, James, MD
Munisamy, Malathy, MD
Vaishnaw, Akshay K, MD
Gollob, Jared A, MD
Simon, Amy, MD
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4387547
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4387547
Other Identifiers
ISSN
0140-6736
E-ISSN
1474-547X
DOI
10.1016/S0140-6736(13)61914-5
