SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer
SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as tumor suppressors in modulating oncogenic signaling pathways. We report here that SMARCE1 loss induces EGFR expression and confers resistance to MET and ALK inhibitors in non-small cell lung ca...
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SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4387553
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4387553
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ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2015.16
