A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
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Author / Creator
Di Stefano, M , Nascimento-Ferreira, I , Orsomando, G , Mori, V , Gilley, J , Brown, R , Janeckova, L , Vargas, M E , Worrell, L A , Loreto, A , Tickle, J , Patrick, J , Webster, J R M , Marangoni, M , Carpi, F M , Pucciarelli, S , Rossi, F , Meng, W , Sagasti, A , Ribchester, R R , Magni, G , Coleman, M P and Conforti, L
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this activity is lost. However, whether axon survival is re...
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Full title
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4392071
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4392071
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2014.164
