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A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4392071

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

About this item

Full title

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Publisher

London: Nature Publishing Group UK

Journal title

Cell death and differentiation, 2015-04, Vol.22 (5), p.731-742

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this activity is lost. However, whether axon survival is re...

Alternative Titles

Full title

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4392071

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4392071

Other Identifiers

ISSN

1350-9047

E-ISSN

1476-5403

DOI

10.1038/cdd.2014.164

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