Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophag...
Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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United States: American Society for Clinical Investigation
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Contents
Cherubism is a rare autoinflammatory bone disorder that is associated with point mutations in the SH3-domain binding protein 2 (SH3BP2) gene, which encodes the adapter protein 3BP2. Individuals with cherubism present with symmetrical fibro-osseous lesions of the jaw, which are attributed to exacerbated osteoclast activation and defective osteoblast...
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Full title
Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4396483
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4396483
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI71081
