Functional annotation of native enhancers with a Cas9–histone demethylase fusion
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Targeting a histone demethylase to specific enhancers with Cas9 allows modification of epigenetic marks at the enhancers.
Understanding of mammalian enhancers is limited by the lack of a technology to rapidly and thoroughly test the cell type–specific function. Here, we use a nuclease-deficient Cas9 (dCas9)–histone demethylase fusion to function...
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Full title
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4414811
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4414811
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth.3325
