Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the P...
Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/ AKT signaling pathway
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Aim： Blockade of EGFR by EGFR tyrosine kinase inhibitors such as erlotinib is insufficient for effective treatment of human pancreatic cancer due to independent activation of the Akt pathway, while amiloride, a potassium-sparing diuretic, has been found as a potential Akt inhibitor. The aim of this study was to investigate the anticancer effects of...
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Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/ AKT signaling pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4422948
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4422948
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1671-4083
E-ISSN
1745-7254
DOI
10.1038/aps.2015.4
