Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
L-
Oligonucleotide aptamers (Spiegelmers) consist of non-natural
L-
configured nucleotides and are of particular therapeutic interest due to their high resistance to plasma nucleases. The anaphylatoxin C5a, a potent inflammatory mediator generated during complement activation that has been implicated with organ damage, can be efficiently t...
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Full title
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4423239
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4423239
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms7481
