Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
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Author / Creator
FALS Sequencing Consortium , FALS Sequencing Consortium , Cirulli, Elizabeth T. , Lasseigne, Brittany N. , Petrovski, Slavé , Sapp, Peter C. , Dion, Patrick A. , Leblond, Claire S. , Couthouis, Julien , Lu, Yi-Fan , Wang, Quanli , Krueger, Brian J. , Ren, Zhong , Keebler, Jonathan , Han, Yujun , Levy, Shawn E. , Boone, Braden E. , Wimbish, Jack R. , Waite, Lindsay L. , Jones, Angela L. , Carulli, John P. , Day-Williams, Aaron G. , Staropoli, John F. , Xin, Winnie W. , Chesi, Alessandra , Raphael, Alya R. , McKenna-Yasek, Diane , Cady, Janet , de Jong, J. M. B. Vianney , Kenna, Kevin P. , Smith, Bradley N. , Topp, Simon , Miller, Jack , Gkazi, Athina , Al-Chalabi, Ammar , van den Berg, Leonard H. , Veldink, Jan , Silani, Vincenzo , Ticozzi, Nicola , Shaw, Christopher E. , Baloh, Robert H. , Appel, Stanley , Simpson, Ericka , Lagier-Tourenne, Clotilde , Pulst, Stefan M. , Gibson, Summer , Trojanowski, John Q. , Elman, Lauren , McCluskey, Leo , Grossman, Murray , Shneider, Neil A. , Chung, Wendy K. , Ravits, John M. , Glass, Jonathan D. , Sims, Katherine B. , Van Deerlin, Vivianna M. , Maniatis, Tom , Hayes, Sebastian D. , Ordureau, Alban , Swarup, Sharan , Landers, John , Baas, Frank , Allen, Andrew S. , Bedlack, Richard S. , Harper, J. Wade , Gitler, Aaron D. , Rouleau, Guy A. , Brown, Robert , Harms, Matthew B. , Cooper, Gregory M. , Harris, Tim , Myers, Richard M. and Goldstein, David B.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment. We report the results of a moderate-scale sequencing study aimed at increasing the number of genes known to contribute to predisposition for ALS. We performed whole-exome sequencing of 2869 ALS patients and 6405 controls. Several known ALS genes w...
Alternative Titles
Full title
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Authors, Artists and Contributors
Author / Creator
FALS Sequencing Consortium
Cirulli, Elizabeth T.
Lasseigne, Brittany N.
Petrovski, Slavé
Sapp, Peter C.
Dion, Patrick A.
Leblond, Claire S.
Couthouis, Julien
Lu, Yi-Fan
Wang, Quanli
Krueger, Brian J.
Ren, Zhong
Keebler, Jonathan
Han, Yujun
Levy, Shawn E.
Boone, Braden E.
Wimbish, Jack R.
Waite, Lindsay L.
Jones, Angela L.
Carulli, John P.
Day-Williams, Aaron G.
Staropoli, John F.
Xin, Winnie W.
Chesi, Alessandra
Raphael, Alya R.
McKenna-Yasek, Diane
Cady, Janet
de Jong, J. M. B. Vianney
Kenna, Kevin P.
Smith, Bradley N.
Topp, Simon
Miller, Jack
Gkazi, Athina
Al-Chalabi, Ammar
van den Berg, Leonard H.
Veldink, Jan
Silani, Vincenzo
Ticozzi, Nicola
Shaw, Christopher E.
Baloh, Robert H.
Appel, Stanley
Simpson, Ericka
Lagier-Tourenne, Clotilde
Pulst, Stefan M.
Gibson, Summer
Trojanowski, John Q.
Elman, Lauren
McCluskey, Leo
Grossman, Murray
Shneider, Neil A.
Chung, Wendy K.
Ravits, John M.
Glass, Jonathan D.
Sims, Katherine B.
Van Deerlin, Vivianna M.
Maniatis, Tom
Hayes, Sebastian D.
Ordureau, Alban
Swarup, Sharan
Landers, John
Baas, Frank
Allen, Andrew S.
Bedlack, Richard S.
Harper, J. Wade
Gitler, Aaron D.
Rouleau, Guy A.
Brown, Robert
Harms, Matthew B.
Cooper, Gregory M.
Harris, Tim
Myers, Richard M.
Goldstein, David B.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4437632
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4437632
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaa3650
